How Cannabidiol (CBD) can replace these drugs
The endocannabinoid system (ECS), has two primary cannabinoid receptors in the central and peripheral nervous systems which respond to endocannabinoids (body-produced cannabinoids) and phytocannabinoids (cannabinoids from plants) to regulate pain, appetite, mood, and other physiological processes, like inflammation.
In recent years, researchers have begun to uncover the possibilities of using phytocannabinoids as an alternative treatment for a variety of illnesses and diseases, including anxiety disorders. In particular, Cannabidiol (CBD) has been shown to be an effective treatment for anxiety without generating any of the psychoactive effects typically associated with cannabis.
CBD Boosts Serotonin Receptors
Serotonin receptors are found all over the brain, including the amygdala. Serotonin activates these receptors, creating a cascade of signals which decrease the heart and respiratory rate, reduce body temperature, produce a calming effect, and decrease anxiety and aggression.
Antidepressants increase serotonin in the brain, but too much serotonin causes the brain to stop releasing serotonin, causing antidepressants to take longer to control anxiety symptoms.
On the other hand, CBD boosts serotonin receptors and inhibits signaling its receptors, causing the brain to continue to release serotonin and achieving the antidepressant effect much faster. Serotonin is one way people use CBD oil for anxiety and depression.
CBD Inhibits the Uptake of GABA
GABA, an inhibitory neurotransmitter, decreases neuron excitability, creating a calming effect and relaxing muscle tone. Low GABA levels can lead to heightened anxiety symptoms. CBD inhibits the uptake of this neurotransmitter. By blocking the reabsorption of GABA, CBD helps control excitatory neurotransmitters.
CBD Inhibits Dopamine Release
Dopamine can be either an excitatory or inhibitory neurotransmitter depending on the part of the brain it acts on and the receptor site to which it binds. Playing a role in “pleasure and reward” feelings, dopamine is commonly referred to as the “feel good” neurotransmitter, creating motivation and energy.
In anxiety disorders, irregular dopamine levels affect how the amygdala interprets the importance of an event. Higher dopamine levels can increase anxiety symptoms.
CBD activates adenosine receptors, which have an important role in regulating blood flow and heart rate, and suppressing the release of excitatory neurotransmitters like dopamine. Activating these receptors with CBD decreases anxiety symptoms by inhibiting the release of dopamine, slowing down the heart rate, and normalizing blood pressure.
CBD Inhibits Glutamate Release
Glutamate, a major excitatory neurotransmitter, plays a role in stress responses, especially how we develop, retain, and prioritize fears.
Lab research on rodents shows that stress affects normal glutamate transmission, and disruption contributes to anxiety. Adenosine receptors regulate the release of glutamate, and CBD activates these receptors, effectively blocking glutamate release.
CBD oil for anxiety and depression
Studies have found when using a placebo pill vs a CBD pill, participants have responded with lower levels of SAD on CBD than placebo.
these studies demonstrate the action of CBD in limbic and paralimbic brain areas, which are known to be associated with anxiety.
the increase of negative self-evaluation during public speaking was almost abolished by CBD.
the effects of a single dose of CBD, observed in this study in the face of one of the main Social Anxiety Disorder (SAD)’s phobic stimuli, is a promising indication of a rapid onset of therapeutic effect in patients with SAD.
We hope this helped you better understand Headery’s CBD Oil for anxiety and depression.
Headery is supporting McMaster University on their upcoming federally funded study in 2019. Focusing on Cannabidiols effect on mood disorders, such a depression, and looking into the compound on a molecular level. The result of our mental health week campaign which enabled the partnership.